Publications

Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging. 2000 Jan-Feb;21(1):89-96.
Torp R, Head E, Milgram NW, Hahn F, Ottersen OP, Cotman CW. Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains. Neuroscience. 2000;96(3):495-506.
Adams B, Chan A, Callahan H, Siwak C, Tapp D, Ikeda-Douglas C, Atkinson P, Head E, Cotman CW, Milgram NW. Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behav Brain Res. 2000 Feb;108(1):47-56.
Milgram NW, Adams B, Callahan H, Head E, Mackay B, Thirlwell C, Cotman CW. Landmark discrimination learning in the dog. Learn Mem. 1999 Jan-Feb;6(1):54-61.
Landsberg GM Cognitive dysfunction advisor. Vet Med (supp), February 1999, 24 pp
Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging. 1998 Sep-Oct;19(5):415-25.
Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res. 1997 Nov 7;774(1-2):35-43.
Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. Open field activity and human interaction as a function of age and breed in dogs. Physiol Behav. 1997 Nov;62(5):963-71.
Landsberg GM, Ruehl WR Geriatric Behavioral problems. 1997, Vet Clin N Am Sm Anim Pract, Geriatric issue, 27 (6), 1537-1559
Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiol Aging. 1996 Jul-Aug;17(4):653-9.
Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem. 1996 Jul;66(1):11-23.
Head E, Hartley J, Kameka AM, Mehta R, Ivy GO, Ruehl WW, Milgram NW. The effects of L-deprenyl on spatial short term memory in young and aged dogs. Prog Neuropsychopharmacol Biol Psychiatry. 1996 Apr;20(3):515-30.
Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. The canine as an animal model of human aging and dementia. Neurobiol Aging. 1996 Mar-Apr;17(2):259-68.
Milgram NW, Ivy GO, Murphy MP, Head E, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Boulton AA. Effects of chronic oral administration of L-deprenyl in the dog. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):421-8.
Ruehl WW, Bruyette DS, DePaoli A, Cotman CW, Head E, Milgram NW, Cummings BJ. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. Prog Brain Res. 1995;106:217-25.
Landsberg GM The most common behavior problems in older dogs Supplement to Vet Med, 90, 1995, 16-24
Ivy GO, Rick JT, Murphy MP, Head E, Reid C, Milgram NW. Effects of L-deprenyl on manifestations of aging in the rat and dog. Ann N Y Acad Sci. 1994 Jun 30;717:45-59.
Milgram NW, Head E, Weiner E, Thomas E. Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. Behavioral Neuroscience, 108 (1): 57-68, 1994
Carrillo MC, Ivy GO, Milgram NW, Head E, Wu P, Kitani K. (-) Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain. Life Sci. 1994;54(20):1483-9.
Milgram NW, Ivy GO, Head E et al. The effect of l-deprenyl on behaviour, cognitive function, and biogenic amines in the dog. Neurochemical Research 1993; 18: 1211-1219
Head E, Milgram NW. Changes in spontaneous behavior in the dog following oral administration of L-deprenyl. Pharmacol Biochem Behav. 1992 Nov;43(3):749-57.