Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. Nutritional management of brain aging in dogs. J Am Vet Med Assoc. 2005 Sep 1;227(5):722-8.
Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):461-9.
Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E. Learning and memory as a function of age in Down syndrome: a study using animal-based tasks. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):443-53.
Boutet I, Ryan M, Kulaga V, McShane C, Christie LA, Freedman M, Milgram NW. Age-associated cognitive deficits in humans and dogs: a comparative neuropsychological approach. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):433-41.
de Rivera C, Boutet I, Zicker SC, Milgram NW. A novel method for assessing contrast sensitivity in the beagle dog is sensitive to age and an antioxidant enriched food. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):379-87.
Nippak PM, Milgram NW. An investigation of the relationship between response latency across several cognitive tasks in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):371-7.
Ikeda-Douglas CJ, de Rivera C, Milgram NW. Pharmaceutical and other commercial uses of the dog model. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):355-60.
Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Murphey H, Muggenburg B, Siwak C, Tapp D, Cotman CW. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiol Aging. 2005 Jan;26(1):77-90.
Landsberg GM, Araujo JA. Behavior as an early sign for dysfunction. DVM In Focus, Senior Care, September 2005, 32-34
Landsberg GM, Araujo J. Behavior Problems in Geriatric Pets. Vet Clin N Am Sm Anim Pract, 2005, 35 (3) pp 675-698
Landsberg GM. Therapeutic agents for the treatment of cognitive dysfunction in dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry, Canine Model of Cognitive Aging: Further Developments and Practical Applications - Edited by C.J. Ikeda-Douglas, C. de Rivera N.W. Milgram, 29, 471-479, 2005
Epstein M, Kuehn N, Landsberg G, et al. AAHA Senior Care Guidelines for Dogs and Cats. JAAHA, 41,81-91,2005
Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats Neurobiology of Aging, 26 (5), 2005, 749-763
Araujo, J.A., Studzinski, C.M., Milgram, N.W. Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Progress in Neuropharmacology and Biological Psychiatry. 2005, 29(3):411-422
Araujo, J.A., Studzinski, C.M., Head, E., Cotman, C.W., Milgram, N.W. Assessment of nutritional interventions for modification of age-associated cognitive decline and brain pathology using a canine model of human aging. 2005, AGE. 27(1):27-37
Studzinski, C.M., Araujo, J.A., Milgram, N.W. The canine model of human cognitive aging and dementia: Pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Progress in Neuropharmacology and Biological Psychiatry. 2005, 29(3):489-498
Chan, J.W.C, Araujo, J.A., Zicker, S.C., Pun, T.W.C., Milgram, N.W. Effect of feeding patterns on performance of a visuospatial memory task in the beagle dog: A novel cognitive-based protocol for assessing satiety. Progress in Neuropharmacology and Biological Psychiatry. 2005, 29(3):481-488
Christie, L.-A., Studzinski, C.M., Araujo, J.A., Leung, C.S.K., Ikeda-Douglas, C.J., Head, E., Cotman, C.W., Milgram, N.W. Age-dependent spatial learning deficits: Characterization of egocentric and allocentric spatial learning in the beagle dog. Progress in Neuropharmacology and Biological Psychiatry. 2005, 29(3):361-369
Tapp, P.D., Chu, Y., Araujo, J.A., Chiou, J.-Y., Head, E., Milgram, N.W., Su, M-Y. Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to asses cerebral blood volume in a canine model of aging. Progress in Neuropharmacology and Biological Psychiatry. 2005 (3):399-406
Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci. 2004 Sep 22;24(38):8205-13.
Milgram NW, Head EA, Zicker SC et al. Long term treatment with antioxidants and a program of behavioral enrichment reduces age-dependant impairment in discrimination and reversal learning in beagle dogs. Exp Gerentol 2004; 39: 753-765
Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav Brain Res. 2004 Aug 12;153(1):199-210.
Ikeda-Douglas CJ, Zicker SC, Estrada J, Jewell DE, Milgram NW. Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles. Vet Ther. 2004 Spring;5(1):5-16.
Landsberg GM, Head E. Aging and effects on behavior. Hoskins JD (ed.) Geriatrics and Gerontology of the Dog and Cat. 2nd ed. Saunders. St. Louis, MO, 2004, 29-42