The brain can be imaged in a variety of different ways, the choice of imaging modality
depending on the research question being answered. Magnetic Resonance Imaging is a very
versatile modality that can provide structural and functional data with new developments
allowing increasingly complex analyses. Magnetic resonance spectroscopy provides a measure
of brain chemistry. Computed Tomography provides more basic structural data, but a strength
of CT is the ability to obtain contrast based regional blood flow and blood volume data.
Positron Emission Tomography can provide exquisite quantitative data on the distribution
of radiolabled compounds. These can be standard labeled compounds such as glucose or
dopamine or custom labeling of test compounds can be developed. These images are routinely
co-registered to CT images for precise anatomical location of the regions of uptake of the
Brain imaging data is well correlated with cognitive function in several species.
CanCog Technologies can provide
cognitive testing services
to support imaging data in several species
Structural Brain Imaging
- MRI or CT to demonstrate structural changes in response to interventions
- T1, T2. PD sequences
- Diffusion Tensor Imaging to evaluate changes in myelination
- Quantitative and qualitative assessment of morphological features or regions of
interest by image processing
Diffusion Tensor Imaging data showing increasing fractional anisotropy in the
frontal lobe, implying increasing myelination with increasing age in young beagle dogs.
Data indicating performance on the landmark allocentric learning improves with
increased myelination in one year old beagle dogs.
Functional Brain Imaging
- Dynamic contrast perfusion to assess blood brain barrier permeability and regional
cerebral blood flow using either MRI or CT
- PET/CT imaging with additional coregistration to MRI images if required to
quantify glucose uptake
- Imaging of brain tissues using standard PET radiopharmaceuticals eg F-18 DOPA
- Imaging of brain tissues with custom developed radiopharmaceuticals linked to
specific naturally occurring brain chemicals or novel compounds
Magnetic Resonance Spectroscopy
Quantification of changes in brain chemistry associated with the development and decline
of neural function in response to therapeutics
Magnetic resonance spectroscopy data showing changes in brain metabolites associated
with brain development in growing beagles, including markers of neuronal health.
Effects of therapeutics can be assessed in attenuating or improving brain development.
Data showing change in concentration of brain metabolites in 10 year old compared to
2 year old beagle dogs