Publications


Araujo JA, Milgram B, de Rivera C, Landsberg. The development of laboratory models for the objective evaluation of anxiolytics in dogs. ACVB/AVSAB Proceedings, Seattle 2009, 2-3
Kogan CS, Boutet I, Cornish K, Graham GE, Berry-Kravis E, Drouin A, Milgram NW. A comparative neuropsychological test battery differentiates cognitive signatures of Fragile X and Down syndrome. J Intellect Disabil Res. 2009 Feb;53(2):125-42.
Christie, L.-A., Opii, W.O., Head, E., Araujo, J.A., de Rivera, C., Milgram, N.W., Cotman, C.W. Short term supplementation with acetyl-l-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Experimental Gerontology 2009, 44(12):752-759
de Rivera, C., Araujo, J.A., Milgram, N.W. Aβ0 and Aβ levels in dog cerebrospinal fluid. 12th International Conference on Alzheimer’s Disease and Related Disorders. , 2009, P4-271
Araujo, J.A., Landsberg, G.M., Milgram, N.W., Miolo, A. (2008) Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E and pyridoxine. Can Vet J. 49(4):379-385
Poma R, Chambers H, da Costa RC, Konyer NB, Nykamp S, Dobson H, Milgram NW. MRI measurement of the canine auditory pathways and relationship with brainstem auditory evoked responses. Vet Comp Orthop Traumatol. 2008;21(3):238-42.
Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioural enrichment: relevance to Alzheimer's disease. Neurobiol Aging. 2008 Jan;29(1):51-70.
Landsberg G, Seksel K. Brain aging and behavioral problems.in senior dogs. Clinician’s Brief. December 2008 (supp) 1-4
Landsberg G, Seksel K. Brain aging and behavior problems in dogs. NAVC Clinicians Brief, December 2008
Landsberg GM. S-adenosylmethionine (SAMe) and cognitive dysfunction in dogs: A roundtable discussion. Advanstar Communications, Lenexa, Kan, 2008:1-8. In: Vet Med 103(7).
Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging. 2008 Jan;29(1):39-50.
Landsberg GM. Cognitive Dysfunction Syndrome. Blackwell’s 5 minute Veterinary Consult: Canine and Feline, p. 266-267, Ames, Iowa, 2007
Chow TW, Pollock BG, Milgram NW. Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease. Neuropsychiatr Dis Treat. 2007;3(5):627-36.
Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. eurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. N Neurobiol Learn Mem. 2007 Sep;88(2):249-59. Epub 2007 Jun 22.
Nippak PM, Mendelson J, Muggenburg B, Milgram NW. Enhanced spatial ability in aged dogs following dietary and behavioural enrichment. Neurobiol Learn Mem. 2007 May;87(4):610-23.
Milgram, N.W., Araujo, J.A., Hagen, T.M., Treadwell, B.V., Ames, B.N. Acetyl-L-carnitine and alpha lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. FASEB. 2007, 21(13):3756-3762
Studzinski, C.M., Christie, L.-A., Araujo, J.A., Burnham, W.M., Head, E., Cotman, C.W., de Rivera, C., Konyer, N.B., Dobson, H., Araujo, J.A., Milgram, N.W. Magnetic resonance spectroscopy reveals similarities in brain metabolites between puppies and kittens. Society for Neuroscience 37th Annual Meeting. 2007, 868.18
de Rivera, C., Araujo, J.A., Milgram, N.W., Rick, J.T., Dobson, H., Konyer, N., Noseworthy, M.D. The dog as a model for studying the effects of cognitive-modifying agents and neuroprotective drugs: Application of brain imaging technologies. Imaging Technology in Drug Discovery & Development. Journal of Alzheimer’s Disease. 2006, 26(1):143-155
Milgram, N.W. Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human cognitive aging and dementia. Neurobiology of Learning and Memory. 2006, 86:197-204
Landsberg GM. Therapeutic options for cognitive decline in senior pets. J Am Anim Hosp Assoc, 2006;42407-413
Milgram, N.W., de Rivera, C., Araujo, J.A., Konyer, N.B., Dobson, H. Changes in beagle brain, assessed by MRI and spectroscopy, are correlated with cognition over the first year of life. Society for Neuroscience 36th Annual Meeting, 2006, 812.1
Milgram, N.W., Siwak-Tapp, C.T., Araujo, J., Head, E. Neuroprotective effects of cognitive enrichment. Ageing Research Reviews. 2006, 5(3):354-369
Nippak PM, Ikeda-Douglas C, Milgram NW. Extensive spatial training does not negate age differences in response latency. Brain Res. 2006 Jan 27;1070(1):171-88.
Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 2006 5;24(15):2824-34.
Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY. Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage. 2006 Jan 1;29(1):234-44. Epub 2005 Nov 7.